Lee, B. SMR i. National Center for Biotechnology InformationU. Monophyly of Rhizaria and Multigene Phylogeny of unicellular Bikonts. In addition to providing the extensive inter-domain interactions that stabilize the structure of the catalytic domains, the unique CgGDE tertiary structure also provides additional contacts for glycogen that mediate its recruitment to glycogen and regulate its activity. Tabata, S. Branching enzymes with this domain architecture are well conserved throughout all kingdoms of life, with homologs possessing all three domains having been found in plants as starch branching enzymes [ 20 ], yeast [ 21 ], and various Bacteria, including E. The interaction between glycogen and CgGDE was assayed by pull-down experiments using glycogen immobilized on concanavalin A conA agarose beads Retrieved February 29,
Looking for online definition of debranching enzyme in the Medical Meaning of debranching enzyme medical term. Collins Dictionary of Biology, 3rd ed.
orf c Glycogen debranching enzyme Saccharolobus solfataricus orf c gene & protein
A debranching enzyme is a molecule that helps facilitate the breakdown of glycogen, which serves as a store of glucose in the body, through glucosyltransferase. F Glycogen debranching enzyme, GlgX type (IPR) glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families.
The monomeric protein contains a central domain in which eight parallel beta-strands are surrounded by eight parallel alpha strands.
Part of the nearby oligosaccharide M is also shown. Both are classified as members of the Glycosyl hydrolase domain GHD superfamily Pfam clan CLwhich contains substrate binding domains of many carbohydrate hydrolases. Patients with Type IIIb generally symptoms related to liver disease.
Phylogenomic analysis of glycogen branching and debranching enzymatic duo
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Debranching enzyme definition in biology
|New York: Wiley; Non-lethal congenital hypotonia due to glycogen storage disease type IV.
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They are also fairly widespread in Bacteria and Archaea. This similarity is largely concentrated at four short conserved sequence regions CSRI—IVwhich contain the catalytic residues in GH13 family members In certain Bacteria e.
Biological process, Glycogen biosynthesis . GO - Molecular functioni. GO - Biological processi. glycogen catabolic process Molecular function, AminopeptidaseImported Glycogen debranching enzyme GlgXImported.
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Automatic. NX_P - AGL - Glycogen debranching enzyme - Function. Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen GO BIOLOGICAL PROCESS.
The red stars in b indicate the active sites.
Refinements were carried out with refmac 59 and phenix Glycogen is a branched glucose polymer and serves as an important energy store.
Proteomics 10— Metabolism : carbohydrate metabolismglycogenesis and glycogenolysis enzymes.